FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term adult olfactory receptor neuron Ir75b ID (Ontology) FBbt:00110016 (Fly Anatomy)
Definition Adult olfactory receptor neuron that expresses the Ionotropic receptor (Ir) 75b and the co-receptor Ir8a (Silbering et al., 2011; Prieto-Godino et al., 2017; Benton et al., 2025). It innervates antennal glomerulus DL2d bilaterally (Prieto-Godino et al., 2017; Benton et al., 2025). Its dendrite transduces signals from antennal coeloconic sensillum ac3 type I (Prieto-Godino et al., 2017). It responds to carboxylic acids and aldehydes (Prieto-Godino et al., 2017; Benton et al., 2025). It develops from an Nab precursor (Benton et al., 2025). There are around 8 of these cells on each side (Schlegel et al., 2021; Benton et al., 2025).[ FlyBase:FBrf0187906 FlyBase:FBrf0206496 FlyBase:FBrf0215822 FlyBase:FBrf0234776 FlyBase:FBrf0249560 FlyBase:FBrf0262710 ]
Also Known As "Ir75b ac3I" ; "ORN (DL2d)" ; "ORN Ac3IA" (for all, see Synonyms field below)
Comment This neuron was directly shown to be olfactory by electrophysiological recordings of a single neuron (Benton et al., 2009). Prieto-Godino et al. (2017) showed that these cells do not express Ir15a and previous detection of Ir75a (Benton et al., 2009) was likely due to transcription of the 5' end of Ir75a at the 3' end of Ir75b transcripts, rather than genuine Ir75a coding transcripts. They also show that cells expressing the Ir75b and Ir75c proteins are distinct (with previous co-occurrence similarly due to transcriptional run off from Ir75c).
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VFB:FBbt_00110016
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 adult olfactory receptor neuron Ir75b (all annotations which use CV term, excluding "NOT" statements)
     adult olfactory receptor neuron Ir75b | somatic clone - tissue specific
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eo neuron
 |__antennal olfactory receptor neuron of coeloconic sensillum__
adult antennal olfactory receptor neuron                        |
 |__antennal olfactory receptor neuron of coeloconic sensillum__|
adult antennal lobe receptor neuron                             |
 |__bilateral antennal lobe receptor neuron_____________________|
                                                                adult olfactory receptor neuron Ir75b  9 rec.
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Is a antennal olfactory receptor neuron of coeloconic sensillum
bilateral antennal lobe receptor neuron
Develops from antennal olfactory receptor neuron precursor Nab
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DoOR:Ir75b
FlyBrain_NDB:10385
VFB:FBbt_00110016