FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term nephrocyte ID (Ontology) FBbt:00047125 (Fly Anatomy)
Definition Cell that regulates hemolymph composition by filtration and filtrate endocytosis. Extensive infoldings of the plasma membrane generate a network of labyrinthine channels, known as lacunae, flanked by nephrocyte foot processes. The entrances to these channels take the form of narrow slits approximately 30 nm in width, spanned by single or double filaments that form a specialized filter known as the nephrocyte diaphragm. Each nephrocyte is enveloped in a negatively charged basement membrane so that hemolymph is filtered across basement membrane and the nephrocyte diaphragm and is endocytosed from the lacunae. Nephrocytes are derived from the embryonic mesoderm and many persist through metamorphosis into adult life.[ FlyBase:FBrf0031012 FlyBase:FBrf0209268 ]
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Data ClassFieldDirect annotations
Alleles (FBal)PHENOTYPE_MANIFEST_IN
Insertions (FBti)EXPRESSION_STAGE_TISSUE_POSITION
Insertions (FBti)PHENOTYPE_MANIFEST_IN
Constructs (FBtp)PHENOTYPE_MANIFEST_IN
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 Alleles Genes Insertions Constructs
 nephrocyte (all annotations which use CV term, excluding "NOT" statements)
     nephrocyte | adult stage
      --       --
     nephrocyte | larval stage
      --       --
     nephrocyte | larval stage | progressive
      --       --
     nephrocyte | third instar larval stage
      --       --
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organ system
 |__excretory system__
cell                  |
 |__somatic cell______|
                      nephrocyte  1056 rec.
                       |__garland cell 468 rec.
                       |   |__adult garland cell 16 rec.
                       |   |__embryonic garland cell 23 rec.
                       |   |__embryonic/larval garland cell 384 rec.
                       |__pericardial cell 591 rec.
                           |__adult pericardial cell(+) 166 rec.
                           |__embryonic pericardial cell(+) 130 rec.
                           |__larval pericardial cell 278 rec.
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