FB2026_02 , released June 18, 2026
Chemical: actinomycin D
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General Information
Name
actinomycin D
FlyBase ID
FBch0000103
ChEBI Name
actinomycin D
ChEBI ID
CHEBI:27666
PubChem Name
Dactinomycin
PubChem ID
CID:457193
Chemical Structure
Chemical structure of actinomycin D
actinomycin D
InChIKey

RJURFGZVJUQBHK-IIXSONLDSA-N

Definition (ChEBI)

ChEBI: Actinomycin D is an actinomycin. It has a role as a mutagen.NCI Thesaurus (NCIt): Dactinomycin is a chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (29)
Synonyms
2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide
(ChEBI, 2019-)
2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
(ChEBI, 2019-)
50-76-0
(PubChem, 2019-)
ACT D
(PubChem, 2019-)
ActD
(ChEBI, 2019-, PubChem, 2019-)
Actinomycin C1
(PubChem, 2019-)
Actinomycin D
(ChEBI, 2019-)
Actinomycin IV
(PubChem, 2019-)
Cosmegen
(PubChem, 2019-)
DACTINOMYCIN
(PubChem, 2019-)
Dactinomycin
(ChEBI, 2019-)
Dactinomycine [INN-French]
(PubChem, 2019-)
Meractinomycin
(PubChem, 2019-)
PubChem:457193
(PubChem, 2019-)
act d
(PubChem, 2019-)
actd
(PubChem, 2019-)
actinomycin
(Kuklin et al., 2017)
actinomycin C1
(ChEBI, 2019-)
actinomycin D
(Park et al., 2023, Wooten et al., 2023, de Faria et al., 2022, Sureka et al., 2022, ChEBI, 2019-, Matveeva et al., 2019, PubChem, 2019-, Raje et al., 2018, Kuklin et al., 2017, Lee et al., 2017, Burow et al., 2015)
actinomycin IV
(ChEBI, 2019-)
actinomycin c1
(PubChem, 2019-)
actinomycin d
(PubChem, 2019-)
actinomycin iv
(PubChem, 2019-)
actinomycin-D
(Lee et al., 2017, Mendelson, 1976)
cosmegen
(PubChem, 2019-)
dactinomycin
(PubChem, 2019-)
dactinomycine [inn-french]
(PubChem, 2019-)
meractinomycin
(PubChem, 2019-)
pubchem:457193
(PubChem, 2019-)
Secondary FlyBase IDs
    References (18)