FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Chemical: (-)-demecolcine
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General Information
Name
(-)-demecolcine
FlyBase ID
FBch0000766
ChEBI Name
(-)-demecolcine
ChEBI ID
CHEBI:4393
PubChem Name
Demecolcine
PubChem ID
CID:220401
Chemical Structure
Chemical structure of (-)-demecolcine
(-)-demecolcine
InChIKey

NNJPGOLRFBJNIW-HNNXBMFYSA-N

Definition (ChEBI)

ChEBI: (-)-demecolcine is a secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It is an alkaloid and a secondary amino compound.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (30)
Synonyms
(-)-Demecolcine
(PubChem, 2019-)
(-)-colchamine
(ChEBI, 2019-)
(-)-demecolcine
(ChEBI, 2019-, PubChem, 2019-, Cai et al., 2017, Dobie et al., 2001)
(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
(ChEBI, 2019-)
477-30-5
(PubChem, 2019-)
Colcemid
(Antel et al., 2022, ChEBI, 2019-, Delanoue et al., 2007)
Colcemide
(PubChem, 2019-)
Colchamine
(PubChem, 2019-)
Demecolcin
(PubChem, 2019-)
Demecolcine
(Gomez et al., 2025, PubChem, 2019-)
Desmecolcine
(PubChem, 2019-)
N-deacetyl-N-methylcolchicine
(ChEBI, 2019-)
N-desacetyl-N-methylcolchicine
(ChEBI, 2019-)
N-methyl-N-deacetylcolchicine
(ChEBI, 2019-)
N-methyl-N-desacetylcolchicine
(ChEBI, 2019-)
PubChem:220401
(PubChem, 2019-)
Reichstein's F
(ChEBI, 2019-, PubChem, 2019-)
Santavy's substance F
(ChEBI, 2019-)
Substance F
(PubChem, 2019-)
colcemid
(Roby and Rauzi, 2025, Villars et al., 2022, PubChem, 2019-, Cai et al., 2017, Pavlova et al., 2016, Ramdas Nair et al., 2016, Weil et al., 2006, Dobie et al., 2001)
colcemide
(PubChem, 2019-)
colchamine
(PubChem, 2019-)
demecolcin
(PubChem, 2019-)
demecolcina
(ChEBI, 2019-)
demecolcine
(Mok and Choi, 2021, ChEBI, 2019-, PubChem, 2019-)
demecolcinum
(ChEBI, 2019-)
desmecolcine
(PubChem, 2019-)
pubchem:220401
(PubChem, 2019-)
reichstein's f
(PubChem, 2019-)
substance f
(PubChem, 2019-)
Secondary FlyBase IDs
    References (15)