FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Chemical: fenfluramine
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General Information
Name
fenfluramine
FlyBase ID
FBch0001028
ChEBI Name
fenfluramine
ChEBI ID
PubChem Name
Fenfluramine
PubChem ID
Chemical Structure
Chemical structure of fenfluramine
fenfluramine
InChIKey

DBGIVFWFUFKIQN-UHFFFAOYSA-N

Definition (ChEBI)

A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (29)
Synonyms
(+-)-fenfluramine
1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane
2-ethylamino-1-(3-trifluoromethylphenyl)propane
3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
458-24-2
Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine
Fenfluramina
Fenfluramine
Fenfluraminum
N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine
N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine
Ponderax PA
Pondimin
PubChem:3337
Rotondin
fenfluramina
ponderax pa
pondimin
pubchem:3337
rotondin
Secondary FlyBase IDs
    References (4)