FB2026_03 , released September 17, 2026
Chemical: Z-DEVD-FMK
Open Close
General Information
Name
Z-DEVD-FMK
FlyBase ID
FBch0001135
ChEBI Name
Z-DEVD-FMK
ChEBI ID
CHEBI:138013
PubChem Name
Z-Devd-fmk
PubChem ID
CID:16760394
Chemical Structure
Chemical structure of Z-DEVD-FMK
Z-DEVD-FMK
InChIKey

GBJVAVGBSGRRKN-JYEBCORGSA-N

Definition (ChEBI)

A tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (28)
Synonyms
210344-95-9
(PubChem, 2019-)
C30H41FN4O12
(PubChem, 2019-)
Caspase-3 Inhibitor
(PubChem, 2019-)
L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
(PubChem, 2019-)
N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide, 1,2-dimethyl ester
(ChEBI, 2019-)
PubChem:16760394
(PubChem, 2019-)
Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone
(PubChem, 2019-)
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone
(PubChem, 2019-)
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
(ChEBI, 2019-)
Z-D(OMe)E(Ome)VD(OMe)-FMK
(PubChem, 2019-)
Z-DEVD-FMK
(ChEBI, 2019-, PubChem, 2019-)
Z-DEVD-fluoromethylketone
(ChEBI, 2019-)
benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
(ChEBI, 2019-, PubChem, 2019-)
benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone
(ChEBI, 2019-)
benzyloxycarbonyl-asp(ome)-glu(ome)-val-asp(ome)-fluoromethylketone
(PubChem, 2019-)
c30h41fn4o12
(PubChem, 2019-)
caspase-3 inhibitor
(PubChem, 2019-)
l-valinamide, n-[(phenylmethoxy)carbonyl]-l-alpha-aspartyl-l-alpha-glutamyl-n-[(1s)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
(PubChem, 2019-)
methyl (4S)-5-{[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino}-4-{[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanoyl]amino}-5-oxopentanoate
(ChEBI, 2019-)
methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
(PubChem, 2019-)
methyl (5S,8S,11S,14S)-14-(fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
(ChEBI, 2019-)
methyl (5s,8s,11s,14s)-14-(2-fluoroacetyl)-11-isopropyl-5-(2-methoxy-2-oxoethyl)-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate
(PubChem, 2019-)
pubchem:16760394
(PubChem, 2019-)
specific inhibitor of caspase-3
(ChEBI, 2019-)
z-asp(o-me)-glu(o-me)-val-asp(o-me) fluoromethyl ketone
(PubChem, 2019-)
z-asp(ome)-glu(ome)-val-asp(ome)-fluoromethylketone
(PubChem, 2019-)
z-d(ome)e(ome)vd(ome)-fmk
(PubChem, 2019-)
z-devd-fmk
(PubChem, 2019-)
Secondary FlyBase IDs
    References (3)