FB2026_03 , released September 17, 2026
Chemical: (S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
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General Information
Name
(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
FlyBase ID
FBch0001155
ChEBI Name
ARS-1620
ChEBI ID
CHEBI:193597
PubChem Name
Ars-1620
PubChem ID
CID:137003167
Chemical Structure
Chemical structure of (S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
InChIKey

ZRPZPNYZFSJUPA-UHFFFAOYSA-N

Definition (ChEBI)

A qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (20)
Synonyms
(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
(ChEBI, 2019-, PubChem, 2019-)
(S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one
(ChEBI, 2019-)
(s)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
(PubChem, 2019-)
1-[4-[(7S)-6-chloro-8-fluoro-7-[(1S)-2-fluoro-6-hydroxyphenyl]-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one
(ChEBI, 2019-)
1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
(PubChem, 2019-)
1-{4-[(7Sa)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl}prop-2-en-1-one
(ChEBI, 2019-)
1698024-73-5
(PubChem, 2019-)
1698055-85-4
(PubChem, 2019-)
1698055-86-5
(PubChem, 2019-)
ARS 1620
(ChEBI, 2019-)
ARS-1323
(PubChem, 2019-)
ARS-1620
(Zhu et al., 2022, PubChem, 2019-)
ARS-1630
(PubChem, 2019-)
ARS1620
(PubChem, 2019-)
CHEMBL4214264
(PubChem, 2019-)
ars-1323
(PubChem, 2019-)
ars-1620
(PubChem, 2019-)
ars-1630
(PubChem, 2019-)
ars1620
(PubChem, 2019-)
chembl4214264
(PubChem, 2019-)
Secondary FlyBase IDs
    References (3)