FB2026_03 , released September 17, 2026
Chemical: 680C91
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General Information
Name
680C91
FlyBase ID
FBch0001337
ChEBI Name
680C91
ChEBI ID
CHEBI:131851
PubChem Name
6-Fluoro-3-((1E)-2-(3-pyridinyl)ethenyl)-1H-indole
PubChem ID
CID:10014426
Chemical Structure
Chemical structure of 680C91
680C91
InChIKey

YBSDQTBCNYWBMX-ONEGZZNKSA-N

Definition (ChEBI)

A fluoroindole that is 6-fluoroindole in which the hydrogen at position 3 has been replaced by a 2-(pyridin-3-yl)vinyl group (trans configuration). It is a selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which directs the conversion of trypophan to kynurenin.

Roles Classification (ChEBI)
Comment

TDO inhibitor (680C91)

(Kashio and Miura, 2020)
Synonyms and Secondary IDs (21)
Synonyms
(E)-6-Fluoro-3-(2-(pyridin-3-yl)vinyl)-1H-indole
(PubChem, 2019-)
(e)-6-fluoro-3-(2-(pyridin-3-yl)vinyl)-1h-indole
(PubChem, 2019-)
163239-22-3
(PubChem, 2019-)
1H-Indole, 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-
(PubChem, 2019-)
1h-indole, 6-fluoro-3-[(1e)-2-(3-pyridinyl)ethenyl]-
(PubChem, 2019-)
6-FLUORO-3-[(E)-2-(PYRIDIN-3-YL)ETHENYL]-1H-INDOLE
(PubChem, 2019-)
6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole
(PubChem, 2019-)
6-fluoro-3-((e)-2-(pyridin-3-yl)ethenyl)-1h-indole
(PubChem, 2019-)
6-fluoro-3-((e)-2-pyridin-3-yl-vinyl)-1h-indole
(PubChem, 2019-)
6-fluoro-3-[(E)-2-(pyridin-3-yl)vinyl]-1H-indole
(ChEBI, 2019-)
6-fluoro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indole
(PubChem, 2019-)
6-fluoro-3-[(e)-2-(pyridin-3-yl)ethenyl]-1h-indole
(PubChem, 2019-)
6-fluoro-3-[(e)-2-pyridin-3-ylethenyl]-1h-indole
(PubChem, 2019-)
680C91
(Kaluski-Kopatch et al., 2025, Kashio and Miura, 2020, ChEBI, 2019-, PubChem, 2019-)
680c91
(PubChem, 2019-)
CHEMBL355606
(PubChem, 2019-)
PubChem:10014426
(PubChem, 2019-)
SCHEMBL3262721
(PubChem, 2019-)
chembl355606
(PubChem, 2019-)
pubchem:10014426
(PubChem, 2019-)
schembl3262721
(PubChem, 2019-)
Secondary FlyBase IDs
    References (5)