FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Chemical: celastrol
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General Information
Name
celastrol
FlyBase ID
FBch0001643
ChEBI Name
celastrol
ChEBI ID
CHEBI:63959
PubChem Name
Celastrol
PubChem ID
CID:122724
Chemical Structure
Chemical structure of celastrol
celastrol
InChIKey

KQJSQWZMSAGSHN-JJWQIEBTSA-N

Definition (ChEBI)

A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (23)
Synonyms
(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
(PubChem, 2019-)
(2R,4aS,6aS,12bR,14aS,14bR)-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-2-picenecarboxylic acid
(ChEBI, 2019-)
(2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
(ChEBI, 2019-, PubChem, 2019-)
(2r,4as,6ar,6as,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
(PubChem, 2019-)
(2r,4as,6as,12br,14as,14br)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
(PubChem, 2019-)
3-hydroxy-9beta,13alpha-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
(ChEBI, 2019-)
34157-83-0
(PubChem, 2019-)
34157-83-0 (castrol)
(PubChem, 2019-)
CHEBI:63959
(PubChem, 2019-)
Celastrol
(Russi et al., 2020)
D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, (20alpha)-
(ChEBI, 2019-)
L8GG98663L
(PubChem, 2019-)
NSC70931
(PubChem, 2019-)
PubChem:122724
(PubChem, 2019-)
Tripterin
(PubChem, 2019-)
Tripterine
(ChEBI, 2019-, PubChem, 2019-)
celastrol
(ChEBI, 2019-, PubChem, 2019-, Sanz et al., 2017, Faust et al., 2009)
chebi:63959
(PubChem, 2019-)
l8gg98663l
(PubChem, 2019-)
nsc70931
(PubChem, 2019-)
pubchem:122724
(PubChem, 2019-)
tripterin
(PubChem, 2019-)
tripterine
(PubChem, 2019-)
Secondary FlyBase IDs
    References (5)