FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Chemical: fumagillin
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General Information
Name
fumagillin
FlyBase ID
FBch0002183
ChEBI Name
fumagillin
ChEBI ID
PubChem Name
Fumagillin
PubChem ID
Chemical Structure
Chemical structure of fumagillin
fumagillin
InChIKey

NGGMYCMLYOUNGM-CSDLUJIJSA-N

Definition (ChEBI)

A meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. ChEBI: Fumagillin is a meroterpenoid resulting from the formal condensation of the hydroxy group of fumagillol with the carboxylic acid group of (all-E)-deca-2,4,6,8-tetraenedioic acid. Originally isolated from the fungus Aspergillus fumigatus, it is used for the control of Nosema infection in honey bees. It has a role as an angiogenesis inhibitor, an antibacterial drug, an antiprotozoal drug, a methionine aminopeptidase 2 inhibitor, an antimicrobial agent and a fungal metabolite. It is an organooxygen heterocyclic antibiotic, a meroterpenoid, a carboxylic ester, a dicarboxylic acid monoester, an antibiotic antifungal drug and a spiro-epoxide. It is functionally related to a fumagillol and an (all-E)-deca-2,4,6,8-tetraenedioic acid.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (17)
Synonyms
(-)-Fumagillin
(2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxodeca-2,4,6,8-tetraenoic acid
2,4,6,8-decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro(2,5)oct-6-yl ester
23110-15-8
Amebacilin
Fumagilina
Fumagillin
Fumagillina
Fumagilline
Fumagillinum
PubChem:6917655
fumagilina
fumagilline
fumagillinum
Secondary FlyBase IDs
    References (3)