FB2026_03 , released September 17, 2026
Chemical: TDZD-8
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General Information
Name
TDZD-8
FlyBase ID
FBch0002410
ChEBI Name
TDZD-8
ChEBI ID
PubChem Name
Tdzd-8
PubChem ID
Chemical Structure
Chemical structure of TDZD-8
TDZD-8
InChIKey

JDSJDASOXWCHPN-UHFFFAOYSA-N

Definition (ChEBI)

A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. ChEBI: TDZD-8 is a member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor, an apoptosis inducer, an antineoplastic agent, a neuroprotective agent and an anti-inflammatory agent. It is a thiadiazolidine and a member of benzenes.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (12)
Synonyms
2-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
327036-89-5
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
GSK-3beta Inhibitor I
GSK-3beta Inhibitor I;NP 01139
PubChem:4124851
thiadiazolidinone-8
Secondary FlyBase IDs
    References (3)