FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Chemical: isoliquiritigenin
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General Information
Name
isoliquiritigenin
FlyBase ID
FBch0002443
ChEBI Name
isoliquiritigenin
ChEBI ID
CHEBI:310312
PubChem Name
Isoliquiritigenin
PubChem ID
CID:638278
Chemical Structure
Chemical structure of isoliquiritigenin
isoliquiritigenin
InChIKey

DXDRHHKMWQZJHT-FPYGCLRLSA-N

Definition (ChEBI)

A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. ChEBI: Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a biological pigment, a NMDA receptor antagonist, a GABA modulator, a metabolite, an antineoplastic agent and a geroprotector. It is functionally related to a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (17)
Synonyms
(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
(ChEBI, 2019-)
(E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone
(ChEBI, 2019-)
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one
(ChEBI, 2019-)
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
(PubChem, 2019-)
2',4',4-Trihydroxychalcone
(PubChem, 2019-)
2',4,4'-TRIHYDROXYCHALCONE
(ChEBI, 2019-)
2',4,4'-Trihydroxychalcone
(ChEBI, 2019-, PubChem, 2019-)
4,2',4'-Trihydroxychalcone
(ChEBI, 2019-, PubChem, 2019-)
6'-deoxychalcone
(PubChem, 2019-)
961-29-5
(PubChem, 2019-)
Chalcone, 2',4,4'-trihydroxy-
(PubChem, 2019-)
GU 17
(PubChem, 2019-)
Isoliquiritigen
(PubChem, 2019-)
Isoliquiritigenin
(ChEBI, 2019-)
PubChem:638278
(PubChem, 2019-)
isoliquiritigenin
(Song et al., 2025, Dai et al., 2024, He et al., 2022, ChEBI, 2019-, PubChem, 2019-)
trans-2',4,4'-trihydroxychalcone
(ChEBI, 2019-)
Secondary FlyBase IDs
    References (5)