FB2026_02 , released June 18, 2026
Chemical: E64
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General Information
Name
E64
FlyBase ID
FBch0002719
ChEBI Name
E64
ChEBI ID
CHEBI:30270
PubChem Name
trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane
PubChem ID
CID:123985
Chemical Structure
Chemical structure of E64
E64
InChIKey

LTLYEAJONXGNFG-DCAQKATOSA-N

Definition (ChEBI)

ChEBI: E64 is an epoxy monocarboxylic acid, a dicarboxylic acid monoamide, a member of guanidines and a L-leucine derivative. It has a role as a protease inhibitor, an antimalarial and an antiparasitic agent. It is a tautomer of an E64 zwitterion.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (15)
Synonyms
(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid
(PubChem, 2019-)
(2S,3S)-3-(N-{(S)-1-[N-(4-guanidinobutyl)carbamoyl]3-methylbutyl}carbamoyl)oxirane-2-carboxylic acid
(ChEBI, 2019-)
(2S,3S)-3-[((1S)-1-{[4-(carbamimidamido)butyl]carbamoyl}-3-methylbutyl)carbamoyl]oxirane-2-carboxylic acid
(ChEBI, 2019-)
66701-25-5
(PubChem, 2019-)
CHEBI:30270
(PubChem, 2019-)
CHEMBL374508
(PubChem, 2019-)
E 64
(ChEBI, 2019-, PubChem, 2019-)
E-64
(ChEBI, 2019-)
E64
(Gatti et al., 2024, ChEBI, 2019-, PubChem, 2019-)
Proteinase inhibitor E 64
(PubChem, 2019-)
PubChem:123985
(PubChem, 2019-)
R76F7856MV
(PubChem, 2019-)
Thiol protease inhibitor
(PubChem, 2019-)
e-64
(PubChem, 2019-)
trans-epoxysuccinyl-L-amido(4-guanido)butane
(Gatti et al., 2024)
Secondary FlyBase IDs
    References (3)