FB2026_03 , released September 17, 2026
Chemical: acivicin
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General Information
Name
acivicin
FlyBase ID
FBch0002766
ChEBI Name
acivicin
ChEBI ID
PubChem Name
Acivicin
PubChem ID
Chemical Structure
Chemical structure of acivicin
acivicin
InChIKey

QAWIHIJWNYOLBE-OKKQSCSOSA-N

Definition (ChEBI)

An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria. ChEBI: Acivicin is an L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria. It has a role as an antimetabolite, a metabolite, an antineoplastic agent, an EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor, an antimicrobial agent, an antileishmanial agent and a glutamine antagonist. It is a member of isoxazoles, an organochlorine compound and a non-proteinogenic L-alpha-amino acid.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (20)
Synonyms
(2S)-amino[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
(alpha-S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
(alphaS,5S)-alpha-amino-3-chloro-2-isoxazoline-5-acetic acid
42228-92-2
Acivicine
Acivicino
Acivicinum
Antibiotic AT 125
NSC 163501
PubChem:294641
U 42126
U-42,126
acivicine
acivicino
acivicinum
Secondary FlyBase IDs
    References (3)