FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Chemical: losmapimod
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General Information
Name
losmapimod
FlyBase ID
FBch0003168
ChEBI Name
losmapimod
ChEBI ID
PubChem Name
Losmapimod
PubChem ID
Chemical Structure
Chemical structure of losmapimod
losmapimod
InChIKey

KKYABQBFGDZVNQ-UHFFFAOYSA-N

Definition (ChEBI)

A secondary carboxamide resulting from the formal condensation of the carboxy group of 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]pyridine-3-carboxylic acid with the amino group of neopentylamine. It is a potent p38alpha/beta mitogen activated protein kinase inhibitor which was previously in clinical trials for the treatment of facioscapulohumeral muscular dystrophy -- trial now discontinued due to not achieving its primary endpoint. ChEBI: 6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide is a phenylpyridine.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (22)
Synonyms
585543-15-3
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide
6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide
F2DQF16BXE
FTX 1821
GW 856553
GW 856553X
GW-856553X
Losmapimod
PubChem:11552706
SB 856553
SB856553
Secondary FlyBase IDs
    References (3)