FB2026_03 , released September 17, 2026
Chemical: tyrphostin B42
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General Information
Name
tyrphostin B42
FlyBase ID
FBch0003281
ChEBI Name
tyrphostin B42
ChEBI ID
PubChem Name
AG-490
PubChem ID
Chemical Structure
Chemical structure of tyrphostin B42
tyrphostin B42
InChIKey

TUCIOBMMDDOEMM-RIYZIHGNSA-N

Definition (ChEBI)

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2<i>E</i>)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (13)
Synonyms
(2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
C4UD8F8XJY
CHEBI:131968
DTXSID5040960
PubChem:5328779
Tyrphostin B42
alpha-Cyano-(3,4-dihydroxy)-N-benzylcinnamide
n-benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
tyrphostin AG-490
tyrphostin B42
Secondary FlyBase IDs
    References (3)