FB2026_03 , released September 17, 2026
Chemical: ICRF-193
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General Information
Name
ICRF-193
FlyBase ID
FBch0003284
ChEBI Name
ICRF-193
ChEBI ID
CHEBI:93771
PubChem Name
Icrf 193
PubChem ID
CID:119081
Chemical Structure
Chemical structure of ICRF-193
ICRF-193
InChIKey

OBYGAPWKTPDTAS-OCAPTIKFSA-N

Definition (ChEBI)

An <em>N</em>-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The <i>meso</i> isomer. ChEBI: ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (15)
Synonyms
2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel-
(PubChem, 2019-)
21416-88-6
(PubChem, 2019-)
4,4'-(2R,3S)-butane-2,3-diyldipiperazine-2,6-dione
(ChEBI, 2019-)
4-[(2S,3R)-3-(3,5-dioxopiperazin-1-yl)butan-2-yl]piperazine-2,6-dione
(PubChem, 2019-)
CHEBI:93771
(PubChem, 2019-)
HEPARIN, SODIUM, LOW MOLECULAR WEIGHT
(PubChem, 2019-)
ICRF 193
(ChEBI, 2019-)
ICRF-193
(ChEBI, 2019-, PubChem, 2019-, Fasulo et al., 2012)
Icrf 193
(PubChem, 2019-)
PubChem:119081
(PubChem, 2019-)
RefChem:147681
(PubChem, 2019-)
meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane
(PubChem, 2019-)
meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane
(ChEBI, 2019-)
meso-4,4'-(1,2-dimethylethylene)di-2,6-piperazinedione
(ChEBI, 2019-, PubChem, 2019-)
meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione)
(ChEBI, 2019-)
Secondary FlyBase IDs
    References (3)