FB2026_03 , released September 17, 2026
Chemical: compound E
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General Information
Name
compound E
FlyBase ID
FBch0003306
ChEBI Name
compound E
ChEBI ID
PubChem Name
Compound E
PubChem ID
Chemical Structure
Chemical structure of compound E
compound E
InChIKey

JNGZXGGOCLZBFB-IVCQMTBJSA-N

Definition (ChEBI)

An <small>L</small>-alanine derivative that is the amide obtained by formal condensation of the carboxy group of <em>N</em>-[(3,5-difluorophenyl)acetyl]-<small>L</small>-alanine with the amino group of (3<i>S</i>)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2<em>H</em>-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (γ-secretase). ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (13)
Synonyms
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide
209986-17-4
C27H24F2N4O3
CHEBI:101713
Compound E
N(2)-((3,5-difluorophenyl)acetyl)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-L-alaninamide
N(2)-[(3,5-difluorophenyl)acetyl]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-L-alaninamide
PubChem:11306390
RefChem:127655
gamma-Secretase Inhibitor XXI
gamma-secretase inhibitor XXI
Secondary FlyBase IDs
    References (3)