FB2026_03 , released September 17, 2026
Chemical: OSMI-1
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General Information
Name
OSMI-1
FlyBase ID
FBch0003375
ChEBI Name
OSMI-1
ChEBI ID
PubChem Name
(alphaR)-alpha-(((1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl)amino)-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)benzeneacetamide
PubChem ID
Chemical Structure
Chemical structure of OSMI-1
OSMI-1
InChIKey

IYIGLWQQAMROOF-HHHXNRCGSA-N

Definition (ChEBI)

A sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2<i>R</i>)-2-amino-<em>N</em>-(2-furylmethyl)-2-(2-methoxyphenyl)-<em>N</em>-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of <em>O</em>-linked β-<em>N</em>-acetylglucosamine transferase (O-GlcNAc transferase, OGT). ChEBI: OSMI-1 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 2-oxo-1,2-dihydroquinoline-6-sulfonic acid with the primary amino group of (2R)-2-amino-N-(2-furylmethyl)-2-(2-methoxyphenyl)-N-(2-thienylmethyl)acetamide. OSMI-1 is a cell permeable inhibitor of O-linked beta-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT). It has a role as an EC 2.4.1.255 (protein O-GlcNAc transferase) inhibitor and an EC 2.* (transferase) inhibitor. It is a tertiary carboxamide, a member of furans, a member of quinolines, a member of thiophenes, a sulfonamide and an aromatic ether.

Roles Classification (ChEBI)
Comment
Synonyms and Secondary IDs (13)
Synonyms
(2R)-N-(2-furylmethyl)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}-N-(2-thienylmethyl)acetamide
(R)-N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide
(alphaR)-alpha-(((1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl)amino)-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)benzeneacetamide
(alphaR)-alpha-[[(1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)benzeneacetamide
1681056-61-0
CHEMBL5559419
DTXCID601536294
DTXSID401104617
PubChem:118634407
RefChem:1050789
Secondary FlyBase IDs
    References (3)