FB2026_03 , released September 17, 2026
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Term chromophore-assisted light inactivation tag ID (Ontology) FBcv:0005041 (FlyBase CV)
Definition Sequence that forms part of the protein encoded by a transgenic locus or modified endogenous locus and which allows a protein to be inactivated by the chromophore-assisted light inactivation (CALI) technique. The tag consists of a peptide sequence that specifically binds a membrane-permeable, chromophore-containing molecule. When activated using a pulse of high-intensity light that is absorbed by the chromophore but not by cellular components, the membrane-permeable molecule generates short-lived reactive oxygen species which inactivate the tagged protein to which the molecule is bound via the chromophore-assisted light inactivation tag.[ PubMed:14625562 PubMed:16605242 PubMed:21226520 PubMed:3399501 ]
Also Known As"CALI tag"
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 chromophore-assisted light inactivation tag (all annotations which use CV term, excluding "NOT" statements)
     encodes tool | chromophore-assisted light inactivation tag       --
     tagged with | chromophore-assisted light inactivation tag       --
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  conditional activity regulation tag
   |__light-regulated activity regulation tag
       |__chromophore-assisted light inactivation tag  6 rec.
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Is a light-regulated activity regulation tag
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