FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: TWO-PORE DOMAIN K+ CHANNEL SUBUNITS
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General Information
Name
TWO-PORE DOMAIN K+ CHANNEL SUBUNITS
Species
D. melanogaster
Symbol
K2P
FlyBase ID
FBgg0000045
Date last reviewed
2023-11-22
Number of members
11
Description
Description
The two-pore domain K+ (K2P) channels possess four transmembrane domains and two pore domains; they assemble as dimers. K2P channels have been implicated in a number of processes such as maintaining resting potential (leak K+ conductance), responding to volatile anesthetics, chemo- and mechanosensation. (Adapted from FBrf0188365 and PMID:11121510).
Notes on Group

FBrf0192007 states that although CG42340 has significant sequence similarity to K2P subunits it only has a single canonical pore signature, so may lack K[+] channel activity.

Source Material
The TWO-PORE DOMAIN K+ CHANNEL SUBUNITS Gene Group has been compiled using the following publication(s): Chintapalli et al., 2013, Döring et al., 2006, and Buckingham et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
potassium channel activity
Biological Process
potassium ion transport
Cellular Component
membrane
Related Gene Groups
Parent group(s)
POTASSIUM CHANNEL SUBUNITS
Members (11)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
K2P
Two-pore domain potassium channels
Tandem of P-domains in a Weakly Inward rectifying K+ channel-related channels
K2P
TWIK
TWO-PORE DOMAIN K+ CHANNELS
TWO-PORE DOMAIN K+ CHANNEL SUBUNITS
Secondary FlyBase ID(s)
References (4)