Gene Group: SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS

General Information

Name

SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS

Species

D. melanogaster

Symbol

SYT

FlyBase ID

FBgg0000083

Date last reviewed

2013-12-12

Number of members

Description

Synaptotagmins are a family of membrane-trafficking proteins characterized by an N-terminal transmembrane region and tandem cytoplasmic C2 domains which mediate specific interactions. Some of the family can interact with lipids in a Ca²⁺-dependent manner, leading to Ca²⁺-regulated release of neurotransmitters and hormones in the nervous and endocrine system. (Adapted from PMID:24065953 and FBrf0210023).

Notes on Group

Rph and Esyt2 are included as they are synaptotagmin-like proteins with a similar domain architecture. btsz tentatively included as a synaptotagmin-like protein - it has tandem C2 domains and can associate with membranes. It does not possess a transmembrane domain. (FBrf0223809 and FBrf0223978).

Source Material

The SYNAPTOTAGMINS & SYNAPTOTAGMIN-LIKE PROTEINS Gene Group has been compiled using the following publication(s): Craxton, 2010, Adolfsen et al., 2004, Craxton, 2004, Adolfsen and Littleton, 2001, Craxton, 2001, and Lloyd et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

calcium-dependent phospholipid binding

Biological Process

neurotransmitter secretion

Cellular Component

membrane

Related Gene Groups

Members (10)

For all members: