FB2026_03 , released September 17, 2026
Gene Group: VPS-C COMPLEX SUBUNITS
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General Information
Name
VPS-C COMPLEX SUBUNITS
Species
D. melanogaster
Symbol
VPS-C
FlyBase ID
FBgg0000106
Date last reviewed
2026-04-15
Number of members
9
Description
Description
The heterohexameric VPS-C complexes, HOPS and CORVET have been extensively characterised in yeast. They interact with SNAREs and Rabs to promote vesicle tethering. The CORVET complex is involved in early endosome fusion, interacting with Rab5-GTP. The HOPS complex interacts with Rab7-GTP on late endosomes (multivesicular bodies) to promote fusion with the lysosomal compartment (and vacuoles) and also autophagosome-lysosome fusion. The VPS-C complexes share common subunits and CORVET to HOPS conversion intermediates (i-CORVET and i-HOPS) have been proposed to accompany early to late endosome maturation. (Adapted from PMID:19575650 and FBrf0223135).
Notes on Group

In metazoans, it is difficult to functionally separate the HOPS and CORVET complexes, but a clearer picture is emerging (see FBrf0187837, FBrf0212933, FBrf0224660 and PMID:25273556).

The core HOPS/CORVET subunits are VSP11, VSP16, VPS18 and VPS33. In metazoans, the yeast VPS33 and VPS16 subunits have two homologs (in D.mel these are car and Vps33B, Vps16A and Vps16B, respectively. These may be complex-specific (FBrf0224660 FBrf0187837 and PMID:25486452).

In D.mel, a putative HOPS complex has been identified. FBrf0224660 demonstrate common role of subunit genes in the fusion of autophagosomes with lysosomes.

No metazoan ortholog for the yeast VPS3 CORVET subunit has been identified (FBrf0223135). Work in C.elegans supports the existence of these the two complexes metazoans (PMID:25273556).

Source Material
The VPS-C COMPLEX SUBUNITS Gene Group has been compiled using the following publication(s): Li and Blissard, 2015, Gillingham et al., 2014, Takáts et al., 2014, Solinger and Spang, 2013, and Pulipparacharuvil et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
endosomal transport
lysosomal transport
autophagosome maturation
Cellular Component
CORVET complex
HOPS complex
Related Gene Groups
Protein Complex group(s)
MON1-CCZ1 COMPLEX
Members (9)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
VPS-C
Class C Vps complex
Homotypic fusion and vacuole protein sorting complex
HOPS complex
Class C core vacuole/endosome tethering complex
CORVET complex
CORVET
HOPS
VPS-C COMPLEXES: HOPS AND CORVET
VPS-C COMPLEX SUBUNITS
Secondary FlyBase ID(s)
References (6)