Ionotropic glutamate receptors (iGluRs) are a highly conserved family of ligand-gated ion channels. They are best characterized for their roles in excitatory synaptic transmission. Upon the binding glutamate, they allow the passage of ions through a channel. iGluRs form heterotetramers - the subunit composition directing the ion selectivity of the receptor. (Adapted from
FBrf0211681).