NMDA receptors are a sub-type of ionotropic glutamate receptor which are selectively activated by the agonist N-Methyl-D-aspartic acid (NMDA). The heterotetrameric complex binds glutamate, allowing the passage of Ca
2+ ions through the channel. They are best characterized for their roles in excitatory synaptic transmission in the CNS. (Adapted from
FBrf0218524 and
FBrf0233872).