FB2026_03 , released September 17, 2026
Complex: MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT
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General Information
Name
MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT
Species
D. melanogaster
Symbol
MRPL
FlyBase ID
FBgg0000181
Date last reviewed
2026-07-01
Number of members
53
Description
Description
Mitochondrial ribosomes are found in the mitochondrial matrix and translate genes involved in oxidative phosphorylation encoded by the mitochondrial genome. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).
Notes on Group

The MITOCHONDRIAL LARGE RIBOSOMAL COMPONENTS gene group includes mitochondrial rRNA.

Based on data from the human orthologs (PMID:25278503), mRpS18A and mRpS30 have been moved from MITOCHONDRIAL SMALL RIBOSOMAL COMPONENTS to the MITOCHONDRIAL LARGE RIBOSOMAL COMPONENTS gene group (FBrf0260754).

Source Material
The MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT Gene Group has been compiled using the following publication(s): Attrill and Marygold, 2024.10.18, Wredenberg et al., 2013, Marygold et al., 2007, and Nakao et al., .
Key Gene Ontology (GO) terms
Molecular Function
structural constituent of ribosome
Biological Process
mitochondrial translation
Cellular Component
mitochondrial large ribosomal subunit
mitochondrial matrix
Related Gene Groups
Parent group(s)
MITOCHONDRIAL RIBOSOMAL SUBUNITS
Members (53)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
MRPL
Large mitochondrial ribosomal subunit
Large mitoribosome
large mitochondrial ribosome
MITOCHONDRIAL LARGE RIBOSOMAL PROTEINS
MITOCHONDRIAL LARGE RIBOSOMAL SUBUNIT
MITOCHONDRIAL LARGE RIBOSOMAL COMPONENTS
Secondary FlyBase ID(s)
References (5)