Gene Group: KINESINS

General Information

Name

KINESINS

Species

D. melanogaster

Symbol

KIF

FlyBase ID

FBgg0000190

Date last reviewed

2023-03-29

Number of members

Description

Kinesin superfamily proteins (KIFs) are microtubule motor proteins which use the hydrolysis of ATP to drive directional movement along microtubules. KIFs possess a well-conserved 360 residue globular head domain which binds and hydrolyses ATP and interacts with microtubules. Many KIFs homodimerize via coiled-coil interactions in the stalk region. KIFs bind cargo through their variable tail regions and are involved in transporting organelles, protein complexes, mRNAs and the movement of spindles and chromosomes during cell division. (Adapted from FBrf0219884).

Notes on Group

Although included in lists of kinesins in FBrf0220063 and FBrf0162187, the CG10845 protein lacks a "Kinesin motor domain" (IPR001752), indicating that it isn't functional as a microtubule motor - it is therefore omitted from this group.

The KINESIN gene group contains kinesins and kinesin-like proteins belonging to the kinesin superfamily. These are also referred to as kinesin heavy chains/motor subunits and do not include kinesin light chains.

The product of CG14535 is predicted not to have microtubule motor activity because a mouse ortholog, Kif26a, has been characterized as an unconventional/atypical kinesin lacking ATPase activity (PMID:19914172) - it is therefore excluded from this group.

Source Material

The KINESINS Gene Group has been compiled using the following publication(s): Kollmar, 2015.9.15, Hirokawa, 2012, Hirokawa, 2012.11.20, Odronitz et al., 2009, Miki et al., 2005, Dagenbach and Endow, 2004, Goshima and Vale, 2003, Miki et al., 2001, and Goldstein and Gunawardena, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

microtubule motor activity

Biological Process

microtubule-based movement

Cellular Component

kinesin complex

Related Gene Groups

Parent group(s)

MICROTUBULE MOTORS

Members (24)

For all members: