Gene Group: PROTEIN-LYSINE N-METHYLTRANSFERASES

General Information

Name

PROTEIN-LYSINE N-METHYLTRANSFERASES

Species

D. melanogaster

Symbol

KMT

FlyBase ID

FBgg0000272

Date last reviewed

2015-06-08

Number of members

Description

Protein-lysine N-methyltransferases catalyze the transfer of methyl group from S-adenosyl methionine to epsilon-amino group of a lysine residues of key cellular and nuclear proteins as well as histone substrates. Lysine residues can be mono-, di-, or trimethylated.

Notes on Group

Blimp-1 has not been included. It is a member of the Prdm family that are characterized by an N-terminal PR domain that is related to the SET methyltransferase domain. Often, members of this family are not catalytically active and Blimp-1 is orthologous to human PRDM1, which does not display methyltransferase activity. (FBrf0219140).

Source Material

The PROTEIN-LYSINE N-METHYLTRANSFERASES Gene Group has been compiled using the following publication(s): Jiang et al., 2017, Calpena et al., 2015, Shilatifard, 2012, Mohan et al., 2011, Thompson and Travers, 2008, Mis et al., 2006, Dillon et al., 2005, and Schotta et al., 2004 .

Key Gene Ontology (GO) terms

Molecular Function

protein-lysine N-methyltransferase activity

Biological Process

peptidyl-lysine methylation

Cellular Component

Related Gene Groups

Parent group(s)

PROTEIN METHYLTRANSFERASES

Component group(s)

SET AND MYND DOMAIN FAMILY

SET DOMAIN LYSINE METHYLTRANSFERASES