FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein-lysine N-methyltransferase activity ID (Ontology) GO:0016279 (Gene Ontology)
Definition Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.[ PubMed:12054878 ]
Also Known As"protein (lysine) methyltransferase activity" ; "protein lysine methylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein-lysine N-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein-lysine N-methyltransferase activity       --
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methyltransferase activity
 |__protein methyltransferase activity_____________________
N-methyltransferase activity                               |
 |__lysine N-methyltransferase activity____________________|
S-adenosylmethionine-dependent methyltransferase activity  |
 |__lysine N-methyltransferase activity____________________|
catalytic activity, acting on a protein                    |
 |__protein methyltransferase activity_____________________|
                                                           protein-lysine N-methyltransferase activity  52 rec.
                                                            |__[cytochrome c]-lysine N-methyltransferase activity
                                                            |__calmodulin-lysine N-methyltransferase activity 1 rec.
                                                            |__histone H3K4 methyltransferase activity 16 rec.
                                                            |   |__histone H3K4 dimethyltransferase activity 3 rec.
                                                            |   |__histone H3K4 monomethyltransferase activity 2 rec.
                                                            |   |__histone H3K4 trimethyltransferase activity 3 rec.
                                                            |__histone H3K9 methyltransferase activity 8 rec.
                                                            |   |__histone H3K9 dimethyltransferase activity 2 rec.
                                                            |   |__histone H3K9 monomethyltransferase activity 1 rec.
                                                            |   |__histone H3K9 trimethyltransferase activity 3 rec.
                                                            |   |__histone H3K9me2 methyltransferase activity 1 rec.
                                                            |__histone H3K27 methyltransferase activity 4 rec.
                                                            |   |__histone H3K27 dimethyltransferase activity 1 rec.
                                                            |   |__histone H3K27 monomethyltransferase activity 1 rec.
                                                            |   |__histone H3K27 trimethyltransferase activity 1 rec.
                                                            |__histone H3K36 methyltransferase activity 4 rec.
                                                            |   |__histone H3K36 dimethyltransferase activity 3 rec.
                                                            |   |__histone H3K36 trimethyltransferase activity 1 rec.
                                                            |__histone H3K37 methyltransferase activity
                                                            |__histone H3K56 methyltransferase activity
                                                            |__histone H3K79 methyltransferase activity 1 rec.
                                                            |   |__histone H3K79 dimethyltransferase activity 1 rec.
                                                            |   |__histone H3K79 monomethyltransferase activity 1 rec.
                                                            |   |__histone H3K79 trimethyltransferase activity 1 rec.
                                                            |__histone H4K12 methyltransferase activity 1 rec.
                                                            |__histone H4K20 methyltransferase activity 4 rec.
                                                                |__histone H4K20 monomethyltransferase activity 1 rec.
                                                                |__histone H4K20 trimethyltransferase activity 1 rec.
                                                                |__histone H4K20me methyltransferase activity 1 rec.
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Is a protein methyltransferase activity
lysine N-methyltransferase activity
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Synonyms
  • "protein (lysine) methyltransferase activity" EXACT
    "protein lysine methylase activity" EXACT
Secondary IDs
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Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27"
Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex"
Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB"
Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A"
Reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8"
Reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2"
Reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN"
Reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP"
Reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1"
Reactome:R-HSA-9844111 "EHMT1,EHMT2 trimethylates lysine-16 of ATF7IP"
Reactome:R-HSA-9854315 "CSKMT methylates Citrate Synthase"
RHEA:51000
RHEA:51736
RHEA:54192
RHEA:55544
RHEA:67108