Gene Group: CYTOCHROME C

General Information

Name

CYTOCHROME C

Species

D. melanogaster

Symbol

CYT-C

FlyBase ID

FBgg0000490

Date last reviewed

2026-04-15

Number of members

Description

Cytochrome c is a nuclear-encoded mitochondrial protein involved in electron transfer as part of the mitochondrial electron transport chain. Cytochrome c is located in the mitochondrial intermembrane space and functions as a single electron carrier from ubiquinol-cytochrome c reductase complex to Cytochrome c oxidase. (Adapted from PMID:21296189).

Notes on Group

In mammals cytochrome c is part of the apoptosome complex. It binds to the core subunit, APAF1, initiating apoptosome assembly. In mammals the release of mitochondrial cytochrome c into the cytoplasm is the primary pro-apoptotic signalling event. In Drosophila the requirement for cytochrome c is not clear (FBrf0151953, FBrf0200687 and FBrf0212736).

Source Material

The CYTOCHROME C Gene Group has been compiled using the following publication(s): Porcelli and Marygold, 2014.9.16, Caggese et al., 2006, and Tripoli et al., 2005 .

Key Gene Ontology (GO) terms

Molecular Function

electron transfer activity

Biological Process

oxidative phosphorylation

Cellular Component

mitochondrial intermembrane space

Related Gene Groups

Protein Complex group(s)

MITOCHONDRIAL OXPHOS COMPLEX VARIANTS

Other related group(s)

MITOCHONDRIAL OXPHOS COMPLEX SUBUNITS