FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene Group: HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES
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General Information
Name
HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES
Species
D. melanogaster
Symbol
HSP40
FlyBase ID
FBgg0000504
Date last reviewed
2024-09-18
Number of members
42
Description
Description
The Heat Shock Protein 40 (Hsp40) family of co-chaperones are essential factors in the Hsp70 chaperone cycle. The Hsp40 family is diverse in size and structure, but a number of them are about 40kDa and have been identified as products of heat shock genes. Their defining feature is the DnaJ or J-domain corresponding to the N-terminal 70 amino acids of the Escherichia coli co-chaperone DnaJ. (Adapted from FBrf0173155).
Notes on Group

The gene products of blp and CG1409 have been excluded from the HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES gene group as they lack the functionally important HPD motif of the DnaJ domain(FBrf0134627). blp and CG1409 are Pam16 family proteins, subunits of the mitochondrial presequence translocase-associated motor (PAM) subcomplex of the TIM23 complex.

Source Material
The HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES Gene Group has been compiled using the following publication(s): Deo et al., 2024, Li et al., 2016, and Ratheesh et al., 2012 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
HEAT SHOCK PROTEINS
Members (42)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
HSP40
HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES
DnaJ heat shock proteins
J-proteins
DnaJ domain proteins
Heat shock proteins 40kDa
DnaJ
Secondary FlyBase ID(s)
References (4)