FB2026_03 , released September 17, 2026
Gene Group: SLC3 FAMILY OF HETEROMERIC AMINO ACID TRANSPORTERS ANCILLARY SUBUNITS
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General Information
Name
SLC3 FAMILY OF HETEROMERIC AMINO ACID TRANSPORTERS ANCILLARY SUBUNITS
Species
D. melanogaster
Symbol
SLC3
FlyBase ID
FBgg0000664
Date last reviewed
2024-03-01
Number of members
11
Description
Description
Solute carrier family 3 (SLC3) members encode the heavy chain of heteromeric amino acid transporters (HATs), forming a complex with L-type amino acid transporters of the SLC7 family. The main role of SLC3 proteins is believed to be the routing of the HAT to the plasma membrane. (Adapted from FBrf0207965 and PMID:14770309).
Notes on Group

The SLC3 FAMILY OF HETEROMERIC AMINO ACID TRANSPORTERS ANCILLARY SUBUNITS is only solute carrier family that does not have a transporter function by itself. It debated whether SLC3 should be a SLC class (FBrf0251874).

The 'Maltase' genes were included as SLC3s as they share over 20 % amino acid sequence identity with human SLC3A1.

Source Material
The SLC3 FAMILY OF HETEROMERIC AMINO ACID TRANSPORTERS ANCILLARY SUBUNITS Gene Group has been compiled using the following publication(s): Ceder and Fredriksson, 2022 and Reynolds et al., 2009 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
TRANSMEMBRANE CARRIER PROTEINS
Other related group(s)
L-TYPE AMINO ACID TRANSPORTERS
Members (11)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
SLC3
Heavy subunit of the heteromeric amino acid transports
SLC3 FAMILY OF HETEROMERIC AMINO ACID TRANSPORTERS ANCILLARY SUBUNITS
SOLUTE CARRIER FAMILY 3
Secondary FlyBase ID(s)
References (3)