FB2026_02 , released June 18, 2026
Gene Group: ROUNDABOUT
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General Information
Name
ROUNDABOUT
Species
D. melanogaster
Symbol
ROBO
FlyBase ID
FBgg0000716
Date last reviewed
2017-03-21
Number of members
3
Description
Description
The Roundabout genes encode transmembrane receptors that mediate repulsive cues by binding to midline repellent sli and regulate axon guidance. (Adapted from FBrf0210796).
Notes on Group

In D. melanogaster there is only one slit ligand gene, sli

Source Material
The ROUNDABOUT Gene Group has been compiled using the following publication(s): Evans and Bashaw, 2012, Evans and Bashaw, 2010, Mellert et al., 2010, Pappu and Zipursky, 2010, Santiago-Martinez et al., 2006, Godenschwege et al., 2002, and Rajagopalan et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Roundabout signaling pathway
Cellular Component
plasma membrane
Related Gene Groups
Parent group(s)
TRANSMEMBRANE RECEPTORS
Other related group(s)
COMMISSURELESS
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
ROBO
ROUNDABOUT
Secondary FlyBase ID(s)
References (8)