Prostaglandin synthases use the prostaglandin precursor (PGH[[2)]]) to produce bioactive prostaglandins (PGs), such as PGI[[2]], PGE[[2]], PGF[[2α]], PGD[[2]]. PGs are short-range lipid signaling molecules that act in an autocrine or paracrine fashion to activate G-protein coupled receptors and downstream signaling. (Adapted from FBrf0258648.)
