Rhomboid-like proteins are a family of intramembrane serine proteases related to rho that cleave other transmembrane proteins within their transmembrane domains. Rhomboid proteases are best characterized for their role in epidermal growth factor signaling, where they are required for the production the soluble, secreted ligand. The family includes rhomboid pseudoproteases, that lack catalytic activity. (Adapted from FBrf0235672).