FB2026_03 , released September 17, 2026
Pathway: FGFR SIGNALING PATHWAY
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General Information
Name
FGFR SIGNALING PATHWAY
Species
D. melanogaster
Symbol
FGFR
FlyBase ID
FBgg0000967
Date last reviewed
2025-06-11
Number of members
35
Description
Description
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. FGFR signaling is important in several morphogenic events in Drosophila, notably during mesoderm and tracheal development. (Adapted from FBrf0221038).
Notes and selected reviews

Selected publications for background information: Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster (FBrf0221038), FGF signaling in flies and worms: more and more relevant to vertebrate biology (FBrf0187375), Receptor tyrosine kinases in Drosophila development (FBrf0221727).

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Physical Interaction Network
Members (35)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
FGFR
Fibroblast Growth Factor Receptor Signaling Pathway
FGFR SIGNALING PATHWAY
FGFR Signaling Pathway
Secondary FlyBase ID(s)
References (50)