FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: CPR CUTICLE PROTEIN FAMILY
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General Information
Name
CPR CUTICLE PROTEIN FAMILY
Species
D. melanogaster
Symbol
CPR
FlyBase ID
FBgg0001176
Date last reviewed
2025-11-03
Number of members
103
Description
Description
The largest cuticle protein family, the CPR family, contain a 35 amino acid R&R consensus (named after Rebers and Riddiford, PMID:2462055), which in an extended form has been shown to bind chitin (PMID:15475300). (Adapted from FBrf0242484.)
Notes on Group

FBrf0200175 states that CG15756 and vul came up in the initial survey for cuticular proteins with the R&R Consensus, but 'did not appear to code for cuticular proteins'. Subsequently, FBrf0263657 has shown that vul is localised to the extracellular space between the epidermis and the cuticle and acts as a receptor ligand in wound signaling. CG15756 and vul have therefore been excluded from the CPR CUTICLE PROTEIN FAMILY gene group.

Source Material
The CPR CUTICLE PROTEIN FAMILY Gene Group has been compiled using the following publication(s): Naba et al., 2019.7.9, Cornman, 2009, Magkrioti et al., 2009.10.20, Karouzou et al., 2007, Willis, 2007.1.3, and Andersen et al., 1995 .
Key Gene Ontology (GO) terms
Molecular Function
structural constituent of chitin-based cuticle
Biological Process
Cellular Component
chitin-based extracellular matrix
Related Gene Groups
Parent group(s)
CUTICLE PROTEIN FAMILIES
Members (103)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
CPR
CPR CUTICLE PROTEIN FAMILY
Cuticle Protein Family with Rebers and Riddiford Consensus domain
Cuticle Protein Family with R&R
Secondary FlyBase ID(s)
References (7)