Gene Group: POLY(A) POLYMERASES

General Information

Name

POLY(A) POLYMERASES

Species

D. melanogaster

Symbol

PAPS

FlyBase ID

FBgg0001284

Date last reviewed

2019-12-05

Number of members

Description

Poly(A) polymerases (PAPs) catalyze the addition of nontemplated adenylyl residues to the 3' ends of RNA substrates. In eukaryotes, canonical PAPs polyadenylate mRNAs prior to export from the nucleus to the cytoplasm, which is required for the stabilization, export and efficient translation of transcripts. In contrast, non-canonical PAPs add poly(A) tails to a different types of RNAs to stimulate their degradation - similar to the function of bacterial poly(A) tails. PAPs therefore play crucial and diverse roles in the regulation of gene expression. (Adapted from PMID:21956911.)

Notes on Group

The term 'non-canonical poly(A) polymerases' has been used to describe PAP-related factors that catalyze addition of adenylyl (polyA) or uridylyl (polyU) residues (see PMID:21956911). Only enzymes that have been shown/predicted to catalyze polyadenylation are included in this group - enzymes that catalyze polyuridylation are included in the URIDYLYLTRANSFERASES group.

Source Material

Key Gene Ontology (GO) terms

Molecular Function

poly(A) RNA polymerase activity

Biological Process

RNA processing

Cellular Component

Enzymatic activity

Enzyme name (EC)

polynucleotide adenylyltransferase (2.7.7.19)

Related Gene Groups

Parent group(s)