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General Information
Name
MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS
Species
D. melanogaster
Symbol
MCI-A
FlyBase ID
FBgg0001387
Date last reviewed
2021-02-23
Number of members
30
Description
Description

Mitochondrial Complex I is the first and largest holoenzyme of the mitochondrial electron transport chain. It oxidizes NADH from the tricarboxylic acid cycle and β oxidation of fatty acids, reduces ubiquinone and transports protons across the inner membrane, contributing to the proton-motive force. It is also involved in the cellular production of reactive oxygen species. 'Accessory' or 'supernumerary' subunits are all encoded by nuclear DNA and are not directly involved in catalysis. (Adapted from PMID:23527692 and FBrf0244962.)

Notes on Group

The division between 'CORE' and 'ACCESSORY' Complex I subunits in FlyBase follows that given in FBrf0244962.

These nuclear genes encoding accessory subunits of Complex I exist as paralogs in D. melanogaster: ND-B14.5A and ND-B14.5AL; ND-AGGG and CG40472. In addition, CG11815 and CG12464 have the same InterPro domain (IPR026193) as CG11752 (a NDUFV3 ortholog, FBrf0244962), but no there is no other orthology/literature evidence suggesting they are subunits of Complex I - CG11815 and CG12464 are therefore not included in this group.

Source Material
The MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS Gene Group has been compiled by FlyBase curators using the following publication(s): Rhooms et al., 2020, Garcia et al., 2017, Porcelli and Marygold, 2014.9.16, Porcelli et al., 2007, Caggese et al., 2006, and Tripoli et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
Related Gene Groups
Members (30)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
NADH dehydrogenase (ubiquinone) 42 kDa subunit
ND42, NADH:ubiquinone reductase 42kD subunit precursor, NdufA10
NADH dehydrogenase (ubiquinone) acyl carrier protein
mtacp1, mtACP, NADH-ubiquinone oxidoreductase acyl-carrier subunit, mitochondrial acyl carrier protein 1, ND-AcC
NADH dehydrogenase (ubiquinone) B17 subunit
l(2)35Di, BG:DS09217.1, lethal (2) 35Di, dNDUFB6
NADH dehydrogenase (ubiquinone) SGDH subunit
l(3)neo18, lethal (3) neo18, dNDUFB5
External Data
Synonyms and Secondary IDs
Synonym(s)
MCI-A
MITOCHONDRIAL COMPLEX I - ACCESSORY SUBUNITS
Secondary FlyBase ID(s)
References (7)