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General Information
Name
THREONYL-CARBAMOYL TRANSFERASE COMPLEX
Species
D. melanogaster
Symbol
TCTC
FlyBase ID
FBgg0001634
Date last reviewed
2020-10-09
Number of members
3
Description
Description
The Threonyl-carbamoyl Transferase Complex is an ancient and universally conserved multiprotein complex that catalyzes the transfer of threonyl-carbamoyl to tRNAs, resulting in N6-threonylcarbamoyladenosine (t[6]A) modification at position 37. t[6]A is universal and present in nearly all tRNAs that decode 'ANN' codons. (Adapted from FBrf0223088, PMID:25629598 and PMID:31102979.)
Notes on Group

In mitochondria, the product of Tcs4 (a paralog of Tcs3) functions independently to transfer threonyl-carbamoyl to tRNAs and does not require the other subunits of the TCTC (PMID:25629598).

Source Material
The THREONYL-CARBAMOYL TRANSFERASE COMPLEX Gene Group has been compiled by FlyBase curators using the following publication(s): Rojas-Benítez et al., 2017, Thiaville et al., 2014, and Rojas-Benítez et al., 2013 .
Key Gene Ontology (GO) terms
Molecular Function
Cellular Component
Related Gene Groups
Members (3)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Threonyl-carbamoyl synthesis 5
Prpk, p53-related protein kinase
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TCTC
EKC/KEOPS complex
THREONYL-CARBAMOYL TRANSFERASE COMPLEX
Threonyl-carbamoyl Transferase Complex
Secondary FlyBase ID(s)
References (4)