Aromatic prenyltransferases catalyze the transfer reactions of prenyl moieties onto aromatic acceptors such as phenols, phenolic acids, flavonoids, coumarins, naphthalenes, phenazines, or indole derivatives. They usually catalyze the formation of C-C, C-O, or C-N bonds between the carbon of the prenyl and carbon or functional groups of the aromatic substrates. Membrane-bound or soluble aromatic prenyltransferases exhibit distinct characteristics, such as structural fold, substrate binding motifs, and metal ion dependency. (Adapted from PMID:26216239.)