Complex: RNASE MRP COMPLEX

General Information

Name

RNASE MRP COMPLEX

Species

D. melanogaster

Symbol

RNASEMRP

FlyBase ID

FBgg0001676

Date last reviewed

2023-08-08

Number of members

Description

RNase MRP processes ribosomal RNA (rRNA) precursors at the A3 site allowing formation of the 5.8S pre-rRNA. It is a ribonucleoprotein (RNP) complex, structurally and evolutionary related to the nuclear RNase P, and is found only in eukaryotes. RNase MRP shares most of its protein subunits with nuclear RNase P, though has a distinct catalytic RNA subunit. (Adapted from PMID:16998185 and PMID:20627997.)

Notes on Group

Most protein subunits of yeast and human RNase P are shared with RNase MRP. THe exception is Rpr2/Rpp21, which is known to be unique to RNase P, while there is some evidence that other human RNase P subunits are absent from RNase MRP (see PMID: 20627997). The composition of D. melanogaster RNase MRP has not been assessed,and so all RNase P protein subunits excepting Rpp21 have been included here.

Source Material

The RNASE MRP COMPLEX Gene Group has been compiled using the following publication(s): Manivannan et al., 2015, Schneider et al., 2010, Rosenblad et al., 2006, and Piccinelli et al., 2005 .

Key Gene Ontology (GO) terms

Molecular Function

ribonuclease MRP activity

Biological Process

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Cellular Component

ribonuclease MRP complex

Related Gene Groups

Protein Complex group(s)

NUCLEAR RNASE P COMPLEX

Members (9)

For all members: