Dehydroascorbate reductases are part of the glutathione S-transferase superfamily and catalyze the glutathione (GSH)-dependent reduction of dehydroascorbic acid to ascorbic acid (ascorbate). The ability of ascorbate to donate electrons enables it to act as a free radical scavenger and to reduce higher oxidation states of iron to Fe[2+]. The iron reducing activity of ascorbate maintains the reactive centre Fe[2+] of 2-oxoglutarate-dependent dioxygenases thus preventing inactivation. (Adapted from
PMID:29567393.)
