Gene Group: SOLUBLE GLUTATHIONE S-TRANSFERASES

General Information

Name

SOLUBLE GLUTATHIONE S-TRANSFERASES

Species

D. melanogaster

Symbol

GST-C

FlyBase ID

FBgg0000155

Date last reviewed

2024-07-23

Number of members

Description

Glutathione transferases (glutathione S-transferases, GST) catalyze nucleophilic attack by reduced glutathione on nonpolar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom. At least 14 classes of soluble GSTs have been identified in prokaryotes and eukaryotes: Theta, Omega, Sigma and Zeta exist in all eukaryotes. D. melanogaster has two additional classes, Delta and Epsilon. In D. mel, the class is indicated by the letter after the Gst prefix. (Adapted from FBrf0217315 and PMID:15822171).

Notes on Group

se is an Omega GST.

Gdap1 is not classed as a GST because it "belongs to a new group of GST-like proteins, quite different from all other GST classes...although it is likely that GDAP1-class proteins bind glutathione and perhaps function as glutathione transferases, the cellular context of their functions may be essentially different from those of canonical GSTs." (FBrf0212680).

gfzf is atypical, the GST domain being part of a larger protein and is sometime excluded from analysis of GSTs (FBrf0202224). gfzf has transcriptional coactivator activity and glutathione S-transferase activity and has been localised to the nucleus in some studies (FBrf0250640).

GstD3 and GstT4 are excluded from this group because they display no glutathione transferase activity for any substrate tested (FBrf0217315).

Source Material

The SOLUBLE GLUTATHIONE S-TRANSFERASES Gene Group has been compiled using the following publication(s): Petiot et al., 2024, Gonis et al., 2022, Baumann et al., 2018, Wongtrakul et al., 2014, Saisawang et al., 2012, Low et al., 2007, and Marco et al., 2004 .

Key Gene Ontology (GO) terms

Molecular Function

glutathione transferase activity

Biological Process

glutathione metabolic process

Cellular Component

Enzymatic activity

Enzyme name (EC)

glutathione transferase (2.5.1.18)

Related Gene Groups

Parent group(s)

GLUTATHIONE S-TRANSFERASES