Gene Group: GLUTATHIONE S-TRANSFERASES

General Information

Name

GLUTATHIONE S-TRANSFERASES

Species

D. melanogaster

Symbol

GST

FlyBase ID

FBgg0000077

Date last reviewed

2013-07-13

Number of members

Description

Glutathione transferases (glutathione S-transferases, GST) catalyze nucleophilic attack by reduced glutathione on non-polar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom. They have roles in detoxifying xenobiotics and metabolites and in biosynthetic processes. In D. melanogaster, they are divided into two nonhomologous families: the microsomal GSTs and the canonical GSTs that are cytosolic. (Adapted from FBrf0202224 and PMID:15822171.)

Notes on Group

GstD3 and GstT4 are excluded from this group because they display no glutathione transferase activity for any substrate tested (FBrf0217315).

Source Material

The GLUTATHIONE S-TRANSFERASES Gene Group has been compiled using the following publication(s): Petiot et al., 2024, Gonis et al., 2022, Baumann et al., 2018, Wongtrakul et al., 2014, Saisawang et al., 2012, Low et al., 2007, Marco et al., 2004, and Toba and Aigaki, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

glutathione transferase activity

Biological Process

glutathione metabolic process

Cellular Component

Enzymatic activity

Enzyme name (EC)

glutathione transferase (2.5.1.18)

Related Gene Groups

Parent group(s)

ALKYL OR ARYL (NON-METHYL) TRANSFERASES