FB2026_03 , released September 17, 2026
Complex: DRB SENSITIVITY-INDUCING FACTOR COMPLEX
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General Information
Name
DRB SENSITIVITY-INDUCING FACTOR COMPLEX
Species
D. melanogaster
Symbol
DSIF
FlyBase ID
FBgg0001728
Date last reviewed
Number of members
2
Description
Description
The DRB sensitivity-inducing factor (DSIF) complex is a heterodimer that acts as both a positive and negative transcription elongation factor. DSIF together with negative elongation factor (NELF) complex associates with RNA polymerase II and causes transcriptional pausing. Phosphorylation of DSIF-NELF complexes dissociates NELF from the elongation complex and transforms DSIF into a positive elongation factor. (Adapted from FBrf0235113, FBrf0211126 and FBrf0203142).
Notes on Group
Source Material
The DRB SENSITIVITY-INDUCING FACTOR COMPLEX Gene Group has been compiled using the following publication(s): Qiu and Gilmour, 2017, Missra and Gilmour, 2010, and Wu et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
RNA polymerase II complex binding
Biological Process
regulation of transcription elongation by RNA polymerase II
Cellular Component
DSIF complex
Related Gene Groups
Parent group(s)
TRANSCRIPTION ELONGATION FACTOR COMPLEXES
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
DSIF
DRB SENSITIVITY-INDUCING FACTOR COMPLEX
Spt4/5
Secondary FlyBase ID(s)
References (4)