FB2025_05 , released December 11, 2025
Gene Group: NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX BETA SUBUNITS
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General Information
Name
NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX BETA SUBUNITS
Species
D. melanogaster
Symbol
NACB
FlyBase ID
FBgg0001788
Date last reviewed
2022-07-12
Number of members
7
Description
Description
The nascent polypeptide-associated complex (NAC), consisting of alpha and beta subunits, is an essential ribosome-associated protein conserved in eukaryotes. It is a ubiquitously expressed co-translational regulator of nascent protein folding and sorting. Drosophila species, at least, have multiple beta subunit paralogs - one is expressed ubiquitously while others are expressed specifically in the germline. (Adapted from FBrf0253862.)
Notes on Group

βNACtes5 is a pseudogene and is not included in this group.

Source Material
The NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX BETA SUBUNITS Gene Group has been compiled using the following publication(s): Kogan et al., 2022, Kogan et al., 2017, Kogan et al., 2012, Olenkina et al., 2012, Usakin et al., 2005, Braat et al., 2004, and Markesich et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
Cellular Component
nascent polypeptide-associated complex
Related Gene Groups
Parent group(s)
NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNITS
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
NACB
NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX BETA SUBUNITS
Secondary FlyBase ID(s)
References (8)