FB2026_02 , released June 18, 2026
Pathway: CGAS-STING SIGNALING PATHWAY
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General Information
Name
CGAS-STING SIGNALING PATHWAY
Species
D. melanogaster
Symbol
CGAS-STING
FlyBase ID
FBgg0001792
Date last reviewed
2025-06-11
Number of members
7
Description
Description
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an anti-viral pattern recognition pathway. In Drosophila, cyclic GMP-AMP (cGAMP) synthases are activated by viral infection, cGAMP is in turn detected by STING ultimately resulting in the activation the NF-κB-like factor Rel and its translocation into the nucleus to activate the transcription of anti-viral genes. (Adapted from FBrf0252868.)
Notes and selected reviews

Selected publications for background information: cGAS-like receptor-mediated immunity: the insect perspective (FBrf0252868), The antiviral role of NF-κB-mediated immune responses and their antagonism by viruses in insects (FBrf0253361) and An evolutionary perspective to innate antiviral immunity in animals (FBrf0260544).

Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Component group(s)
CGAS-STING SIGNALING PATHWAY CORE COMPONENTS
POSITIVE REGULATORS OF CGAS-STING SIGNALING PATHWAY
Physical Interaction Network
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
CGAS-STING
cGAMP-STING pathway
Cyclic GMP-AMP synthase-stimulator of interferon genes pathway
cGAS/STING Signaling Pathway
CGAS-STING SIGNALING PATHWAY
cGAS-STING Signaling Pathway
Secondary FlyBase ID(s)
References (17)