FB2026_03 , released September 17, 2026
Complex: MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM COMPLEXES
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General Information
Name
MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM COMPLEXES
Species
D. melanogaster
Symbol
MICOS
FlyBase ID
FBgg0001942
Date last reviewed
2026-03-26
Number of members
7
Description
Description
The mitochondrial contact site and cristae organizing system (MICOS) is a large hetero-oligomeric complex inner mitochondrial membrane complex that is involved in the structural maintenance of the inner membrane and cristae formation. (Adapted from FBrf0258588.)
Notes on Group

CG43327, CG14929, CG15296, CG43328 share similarity with MICOS complex subunit Mic13 (QIL1). All four display testis-bias expression so may be testis-specific paralogs, but there is insufficient evidence to support their inclusion in the MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM SUBUNITS gene group.

Source Material
The MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM COMPLEXES Gene Group has been compiled using the following publication(s): Stephan et al., 2024, Benincá et al., 2021, and Huynen et al., 2016 .
Key Gene Ontology (GO) terms
Molecular Function
Biological Process
inner mitochondrial membrane organization
Cellular Component
MICOS complex
Related Gene Groups
Component group(s)
MICOS COMPLEX - MIC10A TESTIS-SPECIFIC VARIANT
MICOS COMPLEX - MIC10B VARIANT
MICOS COMPLEX - MIC10C TESTIS-SPECIFIC VARIANT
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
MICOS
MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM COMPLEXES
MITOCHONDRIAL CONTACT SITE AND CRISTAE ORGANIZING SYSTEM SUBUNITS
Secondary FlyBase ID(s)
References (4)