FB2026_03 , released September 17, 2026
Gene Group: CLC ENDOLYSOSOMAL CHLORIDE/PROTON ANTIPORTERS
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General Information
Name
CLC ENDOLYSOSOMAL CHLORIDE/PROTON ANTIPORTERS
Species
D. melanogaster
Symbol
CLC-EX
FlyBase ID
FBgg0002032
Date last reviewed
2024-09-20
Number of members
2
Description
Description
ClC family endolysosomal chloride/proton antiporters use a pH-gradient to facilitate the the uptake of chloride ions into the lumen of endolysosomal compartments. (Adapted from PMID:29845874.)
Notes on Group

Ostm1 is an obligate accessory subunit for ClC-b.

The CLC family can be divided into two mechanistically different groups: chloride channels (see CLC PLASMA MEMBRANE CHLORIDE CHANNEL SUBUNITS) and chloride/proton-exchangers (this gene group) PMID:29845874.

Source Material
The CLC ENDOLYSOSOMAL CHLORIDE/PROTON ANTIPORTERS Gene Group has been compiled using the following publication(s): Saha et al., 2015, Cabrero et al., 2014, Chintapalli et al., 2013, Rose et al., 2007, and Dow and Davies, 2003 .
Key Gene Ontology (GO) terms
Molecular Function
chloride:proton antiporter activity
Biological Process
lysosomal transport
Cellular Component
lysosomal membrane
Related Gene Groups
Parent group(s)
TRANSMEMBRANE CARRIER PROTEINS
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
CLC-EX
CLC ENDOLYSOSOMAL CHLORIDE/PROTON ANTIPORTERS
Cl-/H+ late endosomal/lysosomal antiporters
CLC endolysosomal Cl-/H+ exchangers
CLC chloride/proton transporters
Secondary FlyBase ID(s)
References (6)